Even outside of the film, they are one. The Substance stars Demi Moore and Margaret Qualley resumed their roles in the body horror film and got into a small "tiff" over whose week it was to be out in the world.

Margaret Qualley's dad Paul Qualley wore a 'Once Upon a Time in Hollywood' t-shirt as her date to the 2025 Golden Globes as a nod to her first major film role. The actress appeared in the 2019 movie alongside fellow emerging stars like Sydney Sweeney and Mikey Madison.