Proceedings of the National Academy of Sciences of the United States of America, Vol. 119, No. 16 (April 19, 2022), pp. 1-10 (10 pages) Allosteric modulators of G-protein-coupled receptors (GPCRs) ...

Opioids slot into opioid receptors and activate them. This sends signals to your brain to relieve pain and promote pleasure. Both endogenous opioids, which your body naturally produces, and exogenous ...

Drugs that target opioid receptors sometimes have severe side effects. Thousands of people around the world die every day from overdoses involving opioids such as fentanyl. Researchers have taken a ...

Researchers at USF Health have discovered a new way opioid receptors can work that may lead to safer pain medications. Their findings show that certain experimental compounds can amplify pain relief ...

New research reveals previously unknown ways opioid receptors can function, opening the door to safer pain treatments.

Scientists have known for decades that opioids relieve pain by binding to molecular switches in the brain called mu-opioid (pronounced "mew-opioid") receptors. What they didn't know - until now - was ...

Visual Abstract. Whole-body [11C] carfentanil PET imaging at baseline (left side of panel) and then following naloxone (middle panel) shows μ-opioid receptor (MOR) in the brain (color) and throughout ...

Opioid agonists are substances that activate opioid receptors in the central and peripheral nervous systems. They have several uses, from pain management to treating opioid use disorder. You have ...

Brain volume and function are altered in individuals with opioid use disorder, a new Yale study finds. Using magnetic resonance imaging (MRI) and functional MRI (fMRI), researchers observed the ...

Opioid receptors are proteins in the nervous system that interact with opioids. Opioid receptors are part of the endogenous opioid system. This is the body’s internal system for regulating pain, ...