Small cell lung cancer is one of the fastest growing and most dangerous types of cancer. It often spreads quickly through the body and is difficult to control. Many patients respond well to treatment ...

Scientists have discovered that losing a key protein in small cell lung cancer triggers inflammation that actually helps ...

A surprising new study reveals that blocking a supposedly protective enzyme, Caspase-2, could actually backfire—raising the risk of chronic liver damage and cancer over time. Researchers found that ...

Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

Expression profiles associated with disease progression in non-small cell lung cancer. Background: Cisplatin is a platinum-based chemotherapeutic drug used for treating a variety of human cancers such ...

Rather than delivering a swift blow to neurons, a death protein found elevated in people with progressive supranuclear palsy (PSP) may exact its toll in a slower, more insidious way. According to a ...

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows. In order to safeguard ...

Scientists use cell death, whether by apoptosis or necrosis, to evaluate the toxicity or effectiveness of substances of interest, including potential therapeutic agents. For example, researchers will ...

Caspases are proteases: enzymes that catalyze the breakdown of proteins and are part of the cysteine–aspartic acid protease family. They are vital to the mechanism of programmed cell death in animals ...

The primary interest of our lab is to investigate the molecular mechanisms of apoptosis and how they impact human health and disease. This focus has evolved to include the investigation of ...