Centrosome duplication is tightly regulated to ensure that centrioles duplicate only once per cell cycle and that only one new centriole is produced per pre-existing centriole Phosphorylation events ...

Initiation of centrosome duplication and DNA replication is coupled, which is primarily achieved by the late G1 phase-specific activation of cyclin-dependent kinase 2 (CDK2)-cyclin E, which triggers ...

A dividing cell duplicates its chromosomes and its centrosome, an organelle that helps divide the two sets of chromosomes equally to daughter cells, just once. Extra centrosome copies can lead to ...

Science paper also describes Orc1’s mechanism of action. Researchers at Cold Spring Harbor Laboratory have discovered the protein that controls the copying of the centrosome in human cells and ...

Cold Spring Harbor, N.Y. – Before a cell can divide into two, first it must duplicate its genetic material--the DNA packed in its chromosomes. The two new sets of chromosomes then have to be separated ...

Biologists at the National University of Singapore (NUS) have uncovered how the protein NuSAP safeguards tiny structures inside cells called centrioles, revealing a mechanism linked to developmental ...

Scientists have unraveled how the cell replication process destabilizes when it has more, or less, than a pair of chromosome sets, each of which is called a genome—a major step toward understanding ...

The lack of a special protein crucial to cell growth and development may help cancer cells proliferate, new research suggests. Cells without this protein – E2F3 – are usually rendered genetically ...