Mitogen-activated protein kinases (MAPKs) are part of an intracellular signaling machinery consisting of three known distinct pathways, each leading to activation of a different protein kinase: p38, ...

August 30, 2007 (Farmingham, CT) – A new mouse study published this week provides some insight into understanding why rofecoxib (Vioxx, Merck) and the other cyclooxygenase (COX)-2 inhibitors increase ...

Reducing Xerostomia by IMRT: What May, and May Not, Be Achieved Since 1992, there have been approximately 10,962 COX-2–related publications and many studies of human cancer have associated its ...

Arachidonic acid (ARA) is metabolized by cyclooxygenase (COX) and cytochrome P450 to produce proangiogenic metabolites. Specifically, epoxyeicosatrienoic acids (EETs) produced from the P450 pathway ...

COX-2 plays a pivotal role in ferroptosis during the progression of chronic liver disease, as it downregulates the Nrf2 signaling pathway, exacerbating ferroptosis, which is characterized by ferrous ...

Randomized Phase III Study of Matrix Metalloproteinase Inhibitor BMS-275291 in Combination With Paclitaxel and Carboplatin in Advanced Non-Small-Cell Lung Cancer: National Cancer Institute of ...