Nature

Induction of gene expression by 5-Aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation ...

Bisulfite-modified genomic DNA as template and the primers MPO-meth. sense 5′-CGGCGGGAAAGGTGGGGTAC-3′ and MPO-meth. antisense 5′-GCTACGAAACCGCTACTTAATAC-3′ were used for amplification of ...
ascopubs.org

The effect of combined therapy with 5-aza-2’-deoxycytidine, sodium butyrate, and tamoxifen on apoptosis of breast cancer cell lines.

In vitro assessment of the inflammatory breast cancer cell line SUM 149: Discovery of two single nucleotide polymorphisms in the RNase L gene. Background: DNA methytransferase inhibitors and histone ...
Nature

Absence of mutations in the deoxycytidine kinase (dCK) gene in patients with relapsed and/or refractory acute myeloid leukemia (AML)

Resistance to chemotherapy is a major problem in the treatment of acute myeloid leukemia (AML). As cytosine-arabinoside (Ara-C) is an important agent in the treatment of AML it is conceivable that ...
ascopubs.org

Phase I study of 5-aza-2’-deoxycytidine in combination with valproic acid in patients with NSCLC

Phase II trial of vorinostat, a histone deacetylase inhibitor to restore the hormone sensitivity to the anti-estrogen tamoxifen in patients with advanced breast cancer having failed prior aromatase ...
Monthly Prescribing Reference

Deoxycytidine Kinase Inhibitor Designated Orphan Drug for Optic Neuritis

Optic neuritis is a rare autoimmune disease characterized by the inflammation of the optic nerve. The Food and Drug Administration (FDA) has granted Orphan Drug designation to TRE-515 for the ...