Severe visual illnesses are increasing in our society, and effective treatments are missing for diseases as age-related macular degeneration, diabetic retinopathy, and glaucoma. Both industry and ...

The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is ...

Grapefruit juice is more than a breakfast staple — it’s a potent enzyme inhibitor that can dramatically alter how certain drugs are metabolized. This article explores how a tiny structural difference ...

Gut bacteria may interact with therapeutic drugs in ways that can result in both reduced microbial fitness or reduced drug efficacy. For example, drugs may be inactivated or otherwise chemically ...

Pharmacogenetics and pharmacogenomics are increasingly recognised as playing a pivotal role in the advancement of personalised medicine, especially in the ...

Cytochromes P450 are a superfamily of enzymes containing heme as a cofactor that function as monooxygenases. Suppressed drug metabolism was identified in patients with various inflammatory conditions.

A new combination of existing drugs reduces the size of cancerous tumors much more effectively than current treatments. A new drug lead shows promise that it could reduce the size of cancerous tumors ...

After a century of false starts, scientists believe they have found a way to make cells burn more energy without the ...

Among the many ways neuroscientists think Alzheimer’s disease may strip away brain function is by disrupting the glucose metabolism needed to fuel the healthy brain. In essence, declining metabolism ...

Developing high-quality, safe, and effective drugs is a complex process that requires varied scientific skills and stringent regulatory assessments. Drug development is a process that spans many years ...