Neurofibromatosis type 1 (NF1) is a genetic condition that raises your risk of tumors, including benign plexiform neurofibromas (PN), which grow along tissues that cover nerves. PN often can’t be ...

Oral selumetinib (AstraZeneca) reduces tumor volume in children with inoperable plexiform neurofibroma, benign tumors of peripheral nerves related to neurofibromatosis type 1 (NF1), with acceptable ...

Neurofibromatosis type 1 (NF1) is a genetic condition that affects the skin, nervous system, and other parts of the body. The condition, formerly called Von Recklinghausen disease, causes changes in ...

CHICAGO -- Selumetinib (Koselugo) significantly improved response rates in adults with neurofibromatosis type 1 (NF1) and symptomatic, inoperable plexiform neurofibromas, the phase III KOMET trial ...

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise from benign plexiform neurofibroma (PN) and borderline atypical neurofibroma (AN) in the setting of ...

I’d like to discuss here the evolving therapeutic landscape in NF1. For the past several years, the NF scientific community, including the UAB NF Research Program, has put major emphasis on conducting ...

Figure 1 (A) Clinical picture, (B) Usg showing intramuscular heterogenous lesion arising from sciatic nerve, (C) MRI showing heterogeneously isointense mass measuring 12.8 × 6.6 × 3.8 cm with features ...

Learning that your child has neurofibromatosis type 1 (NF1) comes with a range of emotions and practical concerns. While many people diagnosed with NF1 will have a normal life expectancy, the ...

Adult and pediatric patients with neurofibromatosis type 1 who have symptomatic plexiform neurofibromas that are not amenable to complete surgical resection are indicated in the approval. Mirdametinib ...

Because NF1 is an unpredictable disorder, it varies widely in severity – even among two people in the same family. Some people with NF1 may be completely unaware that they are affected, experiencing ...