Applying CAR T-cell therapy to treat solid tumors is especially challenging due to the immunosuppressive tumor microenvironment (TME). While our modular RevCAR system enhances the safety and ...
β 2-microglobulin (β2m), the light chain of MHC-I, is required for MHC-I stability and cell-surface expression in tumor cells. 8,9 Increasing evidence has demonstrated that genetic deficiency of B2M ...