Now a December 10, 2013, Alzheimer’s and Dementia paper openly challenges the value of the original findings for human therapy development. Researchers led by Bob Olsson and senior author Kaj Blennow ...
Presenilin proteins have a major role in normal cellular processes, but some contribute to disease, for example through the formation of amyloid-β. The way in which these different roles are regulated ...
To purify the potential target protein, we synthesized a biotinylated derivative of imatinib, ‘biotin-imatinib’ (Supplementary Methods and Supplementary Fig. 3). Solubilized γ-secretase components, ...
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