A team from the UB has described for the first time the molecular self-assembly process of this key protein and has revealed how its active conformation differs from the traditional model accepted for ...

Drugs to treat inflammatory and autoimmune diseases - such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome - act mainly through the glucocorticoid receptor (GR). This essential protein ...

Glucocorticoid receptors are found intracellularly in almost all tissues. Glucocorticoids enter cells through passive diffusion and form a complex with a receptor protein. This complex then undergoes ...

Narrative Review Assesses Current Treatment Challenges and the Evolving Classic Congenital Adrenal Hyperplasia (CAH) Therapeutic Landscape Non-Glucocorticoid (GC) Mechanisms for Treatment of CAH Could ...

Deciphering how the GR forms oligomers—through the binding of several subunits—opens a crucial avenue for developing more selective drugs. These new drugs could modulate this association and thus ...