Advanced engineered cell therapies require gene editing tools that are both precise and efficient. In recent years, CRISPR-Cas9 has emerged as the gold standard for editing genes with greater ...

Cell-autonomous circadian clocks coordinate daily physiological timing, allowing them to synchronize with the environment. However, the initial signaling events shared by diverse synchronizing cues ...

Abnormalities in TDP-43 (Transactive response DNA-binding protein 43 kDa) localization and function span multiple neurodegenerative diseases and are implicated in driving neuronal degeneration and ...

Each cell contains well-defined compartments, each of which has a specific function. The nuclear envelope, for example, is a highly regulated membrane barrier that separates the nucleus from the ...