We retrospectively studied records from patients participating to various prospective clinical trials on CPT-11 in which pharmacokinetic monitoring was involved; the full clinical profiles are ...

Radiation Therapy for Intracranial Germinoma: Results of the German Cooperative Prospective Trials MAKEI 83/86/89 PURPOSE: To determine the safety, pharmacokinetics, and pharmacodynamic effect of 2-[4 ...

Ten subjects received continuous, intravenous infusion of higenamine at gradually escalating doses from 0.5 to 4.0 μg·kg −1 ·min −1, each dose was given for 3 min. Blood and urine samples were ...

Background. Posaconazole is a triazole with anti-Aspergillus activity. However, little is known about the utility of posaconazole as primary therapy for invasive pulmonary aspergillosis. Methods. An ...

New Pharmacokinetic (PK) and Pharmacodynamic Data from Sub-Study in Phase III Trial Strengthens Scientific Basis for RenovoRx ...

Current U.S. physician practices and attitudes in the treatment of peripheral T-cell lymphoma (PTCL). Background: Peripheral T-cell lymphoma (PTCL) has poor prognosis and there is no standard ...

Data from the first in human study on O3R-5671’s potent TNFα inhibition to be presentedDosing of the final cohort in the first in human study has ...

Explore our campus, meet lecturers and current students, and learn more about what it's like to study at Manchester. Qualify as a mathematical modeller with key skills in computational approaches in ...

Minimum inhibitory concentrations (MICs) can be very useful in selecting the best antimicrobial agent for a given patient with known culture and susceptibility results. However, to do so effectively, ...

An integrated evaluation of the pharmacodynamic and pharmacokinetic properties of a drug is essential for successful translation to the clinic. However, cost-effective methods to measure these ...

QRL-101, an oral small molecule being developed by QurAlis, was safe and reduced nerve-cell overactivity in ALS patients in ...