Moxifloxacin (MX) is an 8-methoxyquinolone antimicrobial drug, which is often used as a positive control in thorough QT (TQT) studies. In the present study we established the population ...
A physiologically based pharmacokinetic (PBPK) model developed for suraxavir marboxil (GP681) and its active metabolite GP1707D07 quantitatively predicts clinically relevant drug–drug interactions ...
Although body weight affected pharmacokinetics, the investigators said dosing adjustments based on weight were not warranted. A new report shows the pharmacokinetic properties of Dupixent (dupilumab) ...
PURPOSE: N-(3-Chloro-7-indolyl)-1,4-benzenedisulfonamide (E7070) is a novel sulfonamide anticancer agent currently in phase II clinical development for the treatment of solid tumors. Four phase I ...
In the final pharmacokinetic model, interoccasion variability was estimated to be less than interindividual variability in the clearances for both drugs. The sum of the individual EPI and DTX areas ...
Purpose: To predict midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children. Methods: The absorption and PK of midazolam were simulated using ...
Explore our campus, meet lecturers and current students, and learn more about what it's like to study at Manchester. Qualify as a mathematical modeller with key skills in computational approaches in ...
Y-mAbs Therapeutics, Inc. has presented preclinical and translational pharmacokinetic data of their GD2-SADA bispecific fusion protein at the 2025 Society of Nuclear Medicine & Molecular Imaging ...
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