New research identifies a critical RNA recycling system that prevents cellular "clogging," offering a new path for anti-aging therapies.

Cells in our bodies produce RNA based on genetic information stored in DNA, and RNA serves as a blueprint for making proteins. Researchers at KAIST have discovered a new phenomenon: Removing "circular ...

A study finds that removing accumulated circular RNA slows aging and extends lifespan, with an enzyme preventing toxic RNA buildup, and supporting healthy cellular function across organisms.

RNA interference (RNAi) therapeutics have garnered significant attention in clinical research due to their potential for treating various diseases, including genetic disorders, viral infections and ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Cells rely on tiny molecules called microRNAs to tune which genes are active and when. Cells must carefully control the lifespan of microRNAs to prevent widespread disruption to gene regulation. A new ...

RNA molecules can be modified by enzymes through the addition or removal of chemical groups, but the roles of these modifications in the regulation of both mRNAs and non-coding RNAs are not fully ...

This review is designed by Dr. Junhong Han and written by his postdoctoral researcher Dr. Lei Qiu and PhD student Qian Jing (Research Laboratory of Tumor Epigenetics and Genomics, West China Hospital, ...

Cell fate commitment is achieved by the establishment of cell type-specific transcriptional programs, which in turn are guided, reinforced, and ultimately locked-in by epigenetic mechanisms. In a new ...

Ribonucleic acids (RNAs) are single-stranded molecules that play an essential role in the cells of all living organisms. As "transcripts" of our genes, mRNAs, for example, are involved in the ...

Insects and plants have an important ancient defense mechanism that helps them to fight viruses. This is encoded in their DNA. Scientists have long assumed that vertebrates - including humans - also ...