Elevated serum urate levels are associated with progression of chronic kidney disease. Whether urate-lowering treatment with allopurinol can attenuate the decline of the estimated glomerular ...

In this study conducted in Taiwan, China, Chung and colleagues identified 48 patients with severe allopurinol-related skin reactions and compared their clinical and genetic features with those of 138 ...

The effects of allopurinol treatment on mortality among patients with gout remain uncertain, with a new meta-analysis finding conflicting results. In a systematic review of the literature that ...

Investigators performed post hoc analyses of the CKD-FIX trial, stratifying patients by their CKD stage and serum urate level at baseline. Allopurinol did not slow decline in estimated glomerular ...

Both allopurinol and febuxostat carry similar, significant increased risks for hypersensitivity reactions compared with colchicine, according to data published in Annals of the Rheumatic Diseases.

One of the priority objectives of research into rare diseases is to develop new treatments, and orphan medicines — which target conditions affecting no more than 5 in 10,000 people in the EU — provide ...