This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major ...

Medication overuse headache (MOH) is a widely unrecognized condition, and there is currently no consensus as to how MOH should be managed. This study included 101 patients (mean age 55 years, 89% ...

Triptans are prescription medications that treat migraine attacks after they start. They cannot prevent migraine, but they can ease pain and other symptoms. Triptans calm overactive nerves during an ...

Triptans are effective medicines used to treat migraine headaches. They significantly reduce pain within two hours for most people. Complete relief is less common, but the likelihood may be greater if ...

Triptans have been a go-to acute migraine treatment for decades, and for many people these tried-and-true medications reliably keep full-blown migraine attacks at bay. But that’s not the case for ...

Dr. Carl Dahlöf reviewed four clinical trials involving poor sumatriptan responders and their response to other triptans. All four trials found high likelihood of response to a second triptan. Dahlöf ...

Triptans are serotonin-receptor agonists used in the treatment of migraine headaches. When administered in combination with certain drugs, such as selective serotonin-reuptake inhibitors (SSRIs) and ...

Compared with triptan nonresponders, patients with migraine who report a response to at least 1 triptan have a higher likelihood of responding to treatment with erenumab, according to real-world data ...

Insufficient response to triptans is associated with poor health-related quality of life and lower work productivity in migraineurs compared with those who respond well to the medications, according ...