Scientists have revealed how the electrical patterns formed within an embryo initiate a cascade of molecular changes that culminate in the development of cartilage and bone. Prior studies have shown ...

The study from St. Jude Children's Research Hospital presents a new understanding of how a VGIC, crucial for the communication of neurons and muscle cells, can become unresponsive. Scientists at St.

Ion channels are transmembrane proteins specifically involved with the transport of inorganic ions like Na+, K+, Ca2+, or Cl-. Ion channels are “gated”, i.e. they open in response to a specific ...

Scientists now have a better picture of how voltage-gated sodium (Na v) channels interact with certain animal toxins, thanks to structures solved with cryo-electron microscopy. These channels are ...

The process of expressing a wide variety of voltage-gated and ligand-gated ion channels enables nociceptors to transduce receptor potential into single action potentials or multiple action potentials.

A new study in the Journal of General Physiology (http://www.jgp.org) provides fresh insight into voltage-gated channels—transmembrane ion channels that play a ...

Kv7.2/7.3 channels are voltage-gated potassium channels involved in regulating membrane potential and neuronal excitability.

Muna Therapeutics ApS has disclosed new potassium voltage-gated channel subfamily A member 3 (KCNA3, Kv1.3) channel blockers reported to be useful for the treatment of cancer, neurodegeneration, ...

(A) shows the conventional topology of a voltage-gated potassium channel subunit with six transmembrane domains (S1–S6). Charge carrying residues are indicated on the S4 (red) segment. (B) shows the ...