It appears the illness that limited San Francisco 49ers running back Christian McCaffrey won't have any effect on his Week 15 availability. McCaffrey was not on the Friday injury report, an indicator that he's good to go for Sunday's game against the Tennessee Titans at Levi's Stadium.

Despite a minor scare, Christian McCaffrey will remain in the San Francisco 49ers ' Week 15 lineup when they face the Tennessee Titans. The star running back missed practice early in the week with his illness, but was a full participant on Friday and is expected to play in Week 15, Cam Inman of the Bay Area News Group reported.

The San Francisco 49ers could face a major setback when the 2025 NFL season ends, as Robert Saleh might be on a team's radar for head coach.

His lack of productivity since his return has been head-scratching, but offensive coordinator Klay Kubiak on Thursday in a press conference insisted there isn't an underlying issue. Instead, he pointed to specific examples of missed opportunities in each game.

The San Francisco 49ers return from the bye week looking to win their fourth straight game for the first time since 2023 when they host Tennessee.

Brock Purdy shared a positive toe injury update after the 49ers’ late bye, saying it “feels really good” as San Francisco readies for the Titans.

Eddy Piñeiro nears return, adding WR Javon Baker while releasing Matt Gay and Adrian Martinez to reshape depth.

America First Legal filed a civil rights complaint with the EEOC against the San Francisco 49ers, alleging discriminatory hiring practices under DEI initiatives.

The defense is missing two stars, and everyone assumes that the defense will be the reason the 49ers bow out in the playoffs. However, if the defense forces turnovers, gets stops, and makes plays, yet the 49ers lose because their quarterback is proving that he is not worth the money that they just paid him, that is a real nightmare.