Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 61, No. 2 (MARCH 2012), pp. 219-235 (17 pages) We propose a randomized phase II clinical trial design based on Bayesian ...

Journal of the Royal Statistical Society. Series C (Applied Statistics), Vol. 56, No. 2 (2007), pp. 153-165 (13 pages) Few references deal with response-adaptive randomization procedures for survival ...

Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups. This approach ...

Poly(ADP-ribose) Polymerase Inhibitor Combinations in First-Line Metastatic Castration-Resistant Prostate Cancer: Increasing Toxicity With Unclear Benefits In the article that accompanies this ...

The genetic and clinical heterogeneity of breast cancer makes the identification of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen ...

The heterogeneity of breast cancer makes identifying effective therapies challenging. The I-SPY 2 trial, a multicenter, adaptive phase 2 trial of neoadjuvant therapy for high-risk clinical stage II or ...