Researchers have taken a big step forward in the quest to regenerate the pancreatic beta-cells damaged by type 1 diabetes. Using FDA-approved drugs usually given to patients with rare cancers, they ...

In a clinical trial led by University of Toronto researchers, an allogeneic stem cell–derived islet therapy (zimislecel) restored insulin production and ended severe hypoglycemia in adults with type 1 ...

Borrowing a cancer cell’s disguise, scientists shielded insulin-producing cells from attack by the immune system, a breakthrough that could pave the way for targeted type 1 diabetes treatments without ...

In a recent study published in Nature Communications, researchers used a murine model to demonstrate that functional excision of murine phosphatidylinositol transfer protein alpha (PITPNA) impaired ...

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Beta cells (marked in green) in the pancreas are organized in structures termed islets. In most adults, it was found that a subset become senescent and display the marker p16, shown here in red. The ...

Discover the essential role of TGF-Beta 1 in cellular regulation, its signaling pathway, and how TGF-β1 antibodies are used ...