Credit: Getty Images. The investigational therapy is an oral formulation of synthetic sepiapterin. Sepiapterin significantly reduced blood phenylalanine levels in adult and pediatric patients with ...

The research published recently online on 《Science China-Life Sciences》 led by Prof. Sheng Yang from the Key Laboratory of Synthetic Biology, Chinese Academy of Sciences and a collaborating company, ...

People with phenylketonuria cannot break down a substance in food called phenylalanine. Following a phenylketonuria diet is the main treatment for preventing serious symptoms. People with ...

The FDA approved sepiapterin (Sephience) for the treatment of children and adults with phenylketonuria (PKU), PTC Therapeutics announced. The approval includes broad labeling for the treatment of ...

Sephience (sepiapterin) is a prescription drug that’s used along with a special diet to help lower phenylalanine levels in adults and certain children with phenylketonuria (PKU). Sephience comes as an ...

—According to a new systematic review of the literature, despite early and continuous dietary management to lower phenylalanine levels in patients with phenylketonuria (PKU), cognition may still be ...

Pegvaliase statistically significantly lowered blood Phe levels in adolescents with PKU compared with diet alone. Topline data were announced from a phase 3 trial evaluating pegvaliase-pqpz in ...

A large genetic analysis suggests that one amino acid linked to protein metabolism could influence how long we live, with potential sex-specific effects that challenge assumptions about diet and ...