Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Data are needed on the effect of oxygen delivered through a high-flow nasal cannula, as compared with standard oxygen therapy, on intubation and mortality in patients with acute hypoxemic ...

A 69-year-old man presented with a history of gradual thickening and wrinkling of the skin on the left side of his face. The physical examination showed hyperkeratosis with accentuated ridging, ...

The nonsteroidal mineralocorticoid receptor antagonist finerenone has been reported to improve kidney and cardiovascular outcomes in persons with type 2 diabetes and chronic kidney disease (CKD).

Recent FDA actions related to leucovorin have caused confusion. There is still a lack of scientific evidence establishing that the drug is a safe and effective treatment for autism.

As a legacy of African enslavement, structural racism affects both population and individual health in three interrelated domains: redlining and racialized residential segregation, mass incarceration ...

Patients with atrial fibrillation and a moderate-to-high risk of stroke were randomly assigned, in a 1:1:1 ratio, to receive subcutaneous injection of abelacimab (150 mg or 90 mg once monthly) ...

Explore this issue of The New England Journal of Medicine (Vol. 390 No. 3).

Supported by grants from the Deutsche Forschungsgemeinschaft, a grant (80735240) from the Deutsche Krebshilfe, the Else Kröner Fresenius Stiftung, the Else Kröner Clinician Scientist Program Munich: ...

A 54-year-old woman with metastatic breast cancer who was receiving denosumab therapy presented with right jaw pain. An area of exposed, necrotic bone was visualized in the right mandible.

Explore this issue of The New England Journal of Medicine (Vol. 393 No. 23).

Sotorasib plus Panitumumab in Refractory Colorectal Cancer with Mutated KRAS G12C (N Engl J Med 2023;389:2125-2139). As a result of late data entry, a reanalysis using a later data snapshot (March ...