It’s important to know that an accurate diagnosis of NF1 can only be made by a physician with expertise in the diagnosis and treatment of neurofibromatosis. Because people with NF1 often have multiple ...

Neurofibromatosis is a group of rare genetic disorders that cause benign tumors to form on nerve tissue. Tumors in this disorder are usually noncancerous (benign), but can sometimes become cancerous ...

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise from benign plexiform neurofibroma (PN) and borderline atypical neurofibroma (AN) in the setting of ...

Benign tumors can grow along nerves anywhere in the body, causing complications such as pain, mobility issues, and psychosocial issues. Neurofibromatosis 1-associated plexiform neurofibromas (NF1-PN) ...

Sequences of 529 cancer driver genes were analyzed in 6,381 tumors, yielding 391 NF1-mutated tumors in which NF1 LOH analysis was performed. Driver genes were evaluated by tumor type including ...