A therapy that targets a mutation in a critical tumor suppressor gene exhibited “impressive” activity in a cohort of heavily ...

The study investigated r ezatapopt (PC14586), a first-in-class small molecule designed to selectively bind and reactivate the ...

LG Chem has doubled down on developing an innovative cancer treatment by zeroing in on undruggable targets through a ...

In a groundbreaking review published in Current Molecular Pharmacology, a team led by Dr. Jhi Biau Foo from Taylor’s University unveils the pivotal role of mutant p53 (mutp53) in driving cancer ...

A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...

Discover how TP53 mutations in adult leukaemia impact treatment outcomes and potential strategies for improved patient care.