In a single experiment, scientists can decipher the entire genomes of many patient samples, animal models, or cultured cells.

A computational method called scSurv, developed by researchers at Institute of Science Tokyo, links individual cells to patient outcomes using widely available bulk RNA sequencing data. The approach ...

Understand the stages of a standard RNA-seq bioinformatics workflow, including the role of QC, alignment, gene expression quantification, and specialized application analyses Identify key QC metrics ...

Microscopic images of human tissue are a cornerstone of biomedical research and clinical diagnostics. Yet despite their importance, these images often remain difficult to analyze systematically and to ...

Researchers discovered immune cell aggregates in the gut may signal blood vessel cells and fibroblasts to produce excess collagen, driving fibrosis in Crohn’s disease. The findings could guide ...

A Snakemake-based pipeline called Pipeasm automates key steps of genome assembly, from raw read trimming through scaffolding and contamination screening, and the authors report up to 99.6% BUSCO ...

As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading ...

Scientists at Gladstone Institutes, in collaboration with a team at the San Francisco Veterans Affairs Medical Center, have developed a novel tool—named HIV-seq—for profiling the features of rare ...