Cushing syndrome, which is also called Cushing’s syndrome, is a disorder that happens when your body makes too much of the stress hormone cortisol over a long period of time, according to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Amy Schumer is once again opening up about her Cushing syndrome diagnosis, which all started a year ago when the public began pointing out her “moon face,” she explained on the January 22 episode of the Call Her Daddy podcast.