A novel chimeric antigen receptor T-cell therapy may benefit patients with B-cell lymphomas who previously relapsed following CD19-directed CAR-T, according to results of a phase 1 study.More than 80% ...

During animal development, cells divide and arrange themselves in a coordinated way, eventually forming the embryo. The cells communicate with one another during this process through cell-surface ...

Federal budget cuts have created "a climate of anxiety" among medical researchers, says Maximilian F. Konig, a rheumatologist ...

The discovery of epidermal growth factor receptor (EGFR) mutations in non–small cell lung cancer (NSCLC) has profoundly reshaped treatment paradigms over the past two decades. 1 - 3 While common ...

In cell therapies, engineered receptors need to encompass both safety and efficacy, such as maintaining a resting state until it encounters a disease target. However, the structure of these ...

Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case o ...

High-resolution microscopic images of T cells that have been engineered with TGF-beta SNIPRs (shown in red) as they bind to TGF-beta (shown in green). The SNIPRs activate once the receptors fold into ...

Its End-to-End Platform generates optimal 3S (sensitive, specific and safe) T cell receptors with unique and distinctive attributes that are utilized in multiple therapeutic modalities, such as T ...

Xcellbio and AmplifyBio have an ongoing collaboration aimed at streamlining and improving the manufacturing process for engineered T-cell receptor (TCR) therapies targeting solid tumors, which ...

And that is where T cell receptor therapy has a huge advantage over other types of treatments. T cells have evolved over millions of years to detect precisely this kind of intracellular actor. “Having ...