The Denver Broncos and the San Francisco 49ers will kick off their 2025 preseason at Levi's Stadium on Saturday.

The last NFL preseason game to kick off tonight is the San Francisco 49ers vs. the Denver Broncos in this rivalry matchup.

Here is how 49ers quarterback Mac Jones performed in his long-awaited San Francisco debut against the Denver Broncos in the NFL preseason opener.

The 49ers scored a touchdown on their opening series of the preseason, then their defense crumbled by halftime against the ...

Optimism is running high among die-hard San Francisco 49ers fans as the new NFL season begins, despite the team missing the ...

The San Francisco 49ers didn't have the deepest linebacker room in the team's first preseason game, and it got thinner with ...

SportsLine simulated the new NFL season 10,000 times and revealed its 2025 Fantasy football QB, RB, WR, TE, kicker and ...

The 49ers won't play their starters in their preseason debut against the Denver Broncos, but these 11 players will be worth ...

The 2025 NFL preseason kicked off Thursday and continues through Sunday with several rookies playing their first snaps. Week ...

What to Know The San Francisco 49ers kick off the 2025 NFL preseason against the Denver Broncos on Saturday at Levi’s Stadium ...

Nearly 40 players are brand new to the 49ers’ roster and poised to make their debut in Saturday’s preseason opener against ...

Naturally, Patrick Mahomes went No. 1 overall to the Saints, followed by Josh Allen to the Browns and Lamar Jackson to the ...