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Why do we add citrate to donated blood?🩸🤔 When a unit of packed red blood cells is collected, we need to prevent coagulation inside the bag. Citrate acts as an anticoagulant by chelating (binding) calcium ions. Calcium is a cation, a positively charged ion, and it plays a key role in the coagulation cascade. By binding to calcium, citrate removes it from the reaction, which stops the clotting process from occurring in the stored blood. No calcium = no clotting = stable blood unit ready for tra
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