Anesthesia Buddy on Instagram: "Adenosine ⚡🫀⁣ ⁣ Mechanism of action⁣ Adenosine binds A1 receptors in the AV node → Gi protein activation → ↓ cAMP → ↓ Ca²⁺ influx⁣ Result: hyperpolarization of AV nodal cells and transient AV block⁣ Onset: seconds⁣ Half-life: ~10 seconds (rapid uptake by RBCs and vascular endothelium)⁣ ⁣ Airway & anesthesia implications ⚠️⁣ Can cause bronchospasm via A2B receptors⁣ Avoid or use extreme caution in asthma or reactive airway disease⁣ Expect flushing, chest tightness